肠炎沙门菌活苗免疫次数与保护力的相关研究分享
姜威
(
沃森氏 ( 威海）农牧发展有限公司
, 山东 , 威海 264500
)
董振杰
(
河北玖兴农牧发展有限 公司
, 河北 , 保定 071000
)
王娟
(
山东省乳山市农业农村事务服务中心
, 山东 , 威海 264500
)
本文为科普性文章，涉及动物疾病和治疗方案，应根据适用的法律法规进行，并根据具体情况就医并遵从医嘱。
摘要:
肠炎沙门菌作为一种重要的人畜共患病原，其有效防控是影响公共卫生的一个重要课题。目前市面上已有
多种商品化的活疫苗和灭活疫苗，本文介绍了不同学者对于肠炎沙门菌活疫苗保护力的研究。
沙门菌是自然界中广泛存在的一种革兰阴性菌，目前已知的沙门菌有 2 500 多种血清型。其中肠炎沙门菌已成为一
个全球性问题，给人和动物的健康以及社会经济的发展带来严重威胁。
家禽作为人类重要的食物来源之一，提供了大量的蛋品以及肉制品等。每年因食用被沙门菌污染的鸡蛋而引起的
食品安全问题屡见不鲜。虽然受感染的母鸡可能没有明显的症状，但其产下的鸡蛋却可能已经被污染。其污染过程大
致是在产蛋过程中或产蛋后蛋壳被粪便污染，或者生殖系统感染肠炎沙门菌直接导致蛋形成过程中的污染，从而使最
终成形的鸡蛋受到肠炎沙门菌的污染 [1]。有研究表明蛋壳的污染比蛋内容物的污染更常见。
参考文献
[1] Shivaprasad HL, Timoney JF, Morales S, et al.
Pathogenesis of Salmonella Enteritidis infection in laying
chickens. I. Studies on egg transmission, clinical signs, fecal
shedding, and serologic responses[J]. Avian Dis, 1990, 34:548-
57.
[2] Barrow PA, Wallis TS. Vaccination of food animals. In:
Wray C, Wray A, editors. Salmonella in domestic animals[J].
Wallingford: CABI Publishing; 2000: 323-39.
[3] Cogan TA, Humphrey TJ. The rise and fall of Salmonella
Enteritidis in the UK[J]. J Appl Microbiol, 2003, 94:114S–9S.
[4] Desin TS, Köster W, Potter AA. Salmonella vaccines in
poultry: past, present and future[J]. Expert Rev Vacc, 2013,
12:87-96.
[5] Yosef D. Huberman , Alejandra V. Velilla, and Horacio
R. Terzolo. Evaluation of different live Salmonella
enteritidis vaccine schedules administered during layer hen
rearing to reduce excretion, organ colonization, and egg
contamination[J]. Poultry Science, 2019, 98:2422-2431.
[6] Monograph Salmonella Enteritidis vaccine (live, oral)
chickens[J]. European Pharmacopoeia. 2013, 04: 2520.
[7] Inne Gantois, Richard Ducatelle, Leen Timbermont, et
al. Oral immunisation of laying hens with the live vaccine
strains of TAD Salmonella vac® E and TAD Salmonella
vac® T reduces internal egg contamination with Salmonella
Enteritidis[J]. Vaccine, 2006, 24:6250-6255.
[8] Gast RK, Holt PS. The relationship between the
magnitude of the specific antibody response to experimental
Salmonella Enteritidis infection in laying hens and their
production of contaminated eggs[J]. Avian Dis, 2001, 45:425-
31.
[9] Parker C, Asokan K, Guard-Petter J. Egg contamination
by Salmonella serovar Enteritidis following vaccination with
∆ -aroA Salmonella Typhimurium[J]. FEMS Microbiol Lett,
2001, 195:73-8.
[10] Springer S, Lindner T, Ahrens M, et al. Duration
of immunity induced in chickens by an attenuated live
Salmonella enteritidis vaccine and an inactivated Salmonella
enteritidis/typhimurium vaccine[J]. Berl Münch Tierärztl
Wochenschr, 2011, 124:89-93.
[11] Beal RK, Wigley P, Powers C, et al. Cross-reactive
cellular and huoral immune response to Salmonella enterica
serovar Typhimurium and Enteritidis are associated with
protection to heterologous re-challenge[J]. Vet Immunol
Immunopathol, 2006,114: 84-93.
[12] Methner U, Haase A, Berndt A, et al. Exploitation
of intestinal colonization-inhibition between Salmonella
organisms for live vaccines in poultry: potential and
limitations[J]. Zoonoses Public Health, 2011, 58:540-8.
责任编辑: 曹伟胜
