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策略类型 代表方法 作用机制 开发状态
表 2 靶向磷脂代谢的 NDV 防控策略
小分子药物
脂质类似物
诊断技术
疫苗策略
基因编辑
ATP11c/CDC50A 抑制剂
非天然磷脂
脂质组学标志物
代谢佐剂
CRISPR 靶向宿主基因
抑制 PS 翻转，干扰病毒出芽
竞争性抑制病毒组装
识别感染特异性代谢特征
调节免疫细胞代谢，增强免疫原性
切断病毒复制所需的代谢环境
临床前研究
实验验证
部分验证
早期研发
概念验证
17 2026 年第 5 期
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