1982年创刊| ISSN 1008-3847| CN 44-1202/S
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养禽与禽病防治 2026年7期 - 36 -

沙门菌的致病机制、宿主互作与疫苗防控关键

黄秀英 ( 礼蓝 ( 上海 ) 动物保健有限公司 , 上海 , 上海 201423 )
陶林 ( 礼蓝 ( 上海 ) 动物保健有限公司 , 上海 , 上海 201423 )
李晓阳 ( 礼蓝 ( 上海 ) 动物保健有限公司 , 上海 , 上海 201423 )
曹伟胜 ( 华南农业大学兽医学院 , 广东 , 广州 510642 )
中图分类号:S855.1 文献标志码:A 文章编号:1008-3847(2026)07-0036-04
摘要: 沙门菌经口侵入鸡体后,在宿主防御屏障、肠道微环境、免疫细胞攻击以及养殖环境应激的
多重压力下,通过精密的信号调控网络逐级激活毒力基因。胃酸、胆盐、缺氧、氧化应激、吞噬作用、冷
应激以及亚抑菌浓度抗生素等原本是鸡体对抗细菌的有力武器,却可能成为其毒力上调的关键诱导信号。
本文系统解析沙门菌入侵、定殖、免疫逃逸以及全身播散的博弈机制,并阐述疫苗免疫在综合防控策略中
在阻断毒力激活过程中不可替代地位。
关键字: 沙门菌 毒力调控 SPI-1 SPI-2 宿主互作 疫苗免疫 胞内寄生
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责任编辑: 曹伟胜