新型鹅细小病毒研究进展
张艳焱
(
江苏省泰兴市张桥镇畜牧兽医站
, 江苏 , 泰州 225400
)
代保英
(
山东省昌乐县畜牧业发展中心
, 山东 , 潍坊 262400
)
王友
(
天津瑞普生物股份有限公司
, 天津 , 天津 3003502
)
韩金玲
(
天津瑞普生物股份有限公司
, 天津 , 天津 3003502
)
王春璇
(
江苏省连云港市赣榆区畜牧兽医站
, 江苏 , 连云 港 222100
)
王宇飞
(
天津瑞普生物股份有限公司
, 天津 , 天津 3003502
)
中图分类号:S855.3
文献标志码:A
文章编号:1008-3847(2026)09-0002-05
第一作者:张艳焱(1998-),女,硕士,研究方向为畜牧兽医。
* 通讯作者:王宇飞(1998-),硕士,从事动物传染病防控研究。
摘要:
新型鹅细小病毒(Novel goose parvovirus,NGPV)是近年来引起鸭短喙侏儒综合征的重要病原,
给我国肉鸭养殖业造成显著经济损失。NGPV 为经典鹅细小病毒的变异株,VP1 蛋白存在 Q89L、D142E
和 S450N 等特征性突变,使其获得了感染鸭并致病的能力。近年来,NGPV 的流行病学、致病机制、诊
断技术和疫苗研发等方面取得重要进展 :明确了 Rep1 蛋白(而非 VP1)是致病性的关键决定因子,揭示
了 NGPV 与鸭圆环病毒共感染的协同致病效应,建立了 TaqMan qPCR、LAMP 和 RPA-CRISPR 等多种
快速检测方法,灭活疫苗、弱毒活疫苗、VP2 VLPs 亚单位疫苗以及嵌合疫苗等候选疫苗研究也取得突破。
本文就 NGPV 的病原学特征、流行病学、致病机制、诊断方法以及疫苗研发等方面的研究进展进行综述,
以期为该病的防控提供参考。
关键字:
新型鹅细小病毒 短喙侏儒综合征 致病机制 诊断技术 疫苗
参考文献
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疫苗类型 代表株 / 策略 关键数据 研发阶段 文献
表 2 NGPV 候选疫苗研究进展
灭活疫苗
弱毒活疫苗
VLPs 亚单位疫苗
嵌合疫苗
DS15 株
NMG21-35
杆状病毒 -VP2
SYG61v-VP3
实验研究
实验研究
实验研究
专利
中和抗体 1 : 28.5 ( 42 d ),攻毒全保护
P35 代致病性下降,抗体水平升高
攻毒无临床症状,病毒载量显著降低
嵌合病毒安全性良好,有效抵御野毒
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责任编辑: 刁有祥